Photo: Tom Hauck / Getty Images Sport / Getty Images
The Clemson Tigers (3-4) host an ACC battle against the Duke Blue Devils (4-3) on Saturday, November 1, 2025 at Memorial Stadium (Clemson, SC).
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Clemson vs. Duke Matchup Info
- Game date: Saturday, November 1, 2025
- Game time: 12 p.m. ET
- Location: Clemson, South Carolina
- Venue: Memorial Stadium (Clemson, SC)
- TV channel: ACC Network
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Clemson vs. Duke Odds and Prediction
- Spread favorite: Tigers (-3.5)
- Moneyline: Tigers (-163), Blue Devils (+137)
- Total: 54.5 points
- Pick ATS: Duke (+3.5)
- Pick OU: Under (54.5)
- Prediction: Duke 28, Clemson 25
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Clemson vs. Duke Betting Records and Insights
- Clemson has a record of 2-5-0 against the spread this season.
- Duke is 3-4-0 ATS this year.
- The Tigers have covered the spread twice when favored by 3.5 points or more this season (in seven opportunities).
- The Blue Devils have been an underdog by 3.5 points or more this year once, and failed to cover the spread.
- Clemson games have gone over the point total three out of seven times this season.
- So far this year, five of Duke's seven games with a set number have gone over the point total.