According to our computer projections, the New England Patriots will defeat the Carolina Panthers when the two teams play at Gillette Stadium on Sunday, Sept. 28, which begins at 1 p.m. ET. For our predictions on the spead, point total, and final score, check out the rest of the article below.
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Patriots vs. Panthers Game Info and TV Channel
- When: Sunday, September 28, 2025 at 1 p.m. ET
- Where: Gillette Stadium in Foxborough, Massachusetts
- TV: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on 98.5 The Sports Hub
Patriots vs. Panthers Odds and Betting Info
- Spread favorite: Patriots (-5.5)
- Moneyline: Patriots (-249), Panthers (+201)
- Total: 42.5 points
Patriots vs. Panthers Prediction
- Pick ATS: Patriots (-5.5)
- Pick OU: Over (42.5)
Prediction:
Patriots 26 - Panthers 20
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Patriots vs. Panthers Betting Insights
- The Patriots have covered once in three chances against the spread this season.
- The Panthers have a record of 2-1-0 against the spread this season.
- Carolina has been an underdog by 5.5 points or more once this season, and covered the spread.
- Games featuring the Patriots have hit the over once this season.
- Panthers games have gone over the point total once this year.
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