Which team is going to emerge victorious on Sunday, Sept. 21, when the Indianapolis Colts and Tennessee Titans match up at 1 p.m. ET? Our projection model believes in the Colts. See our other projections below, where we break down the final score, spread, and over/under.
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Colts vs. Titans Game Info and TV Channel
- When: Sunday, September 21, 2025 at 1 p.m. ET
- Where: Nissan Stadium in Nashville, Tennessee
- TV: CBS
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
- Live Stream: Watch this game on Paramount+ (Regional restrictions may apply)
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Colts vs. Titans Odds and Betting Info
- Spread favorite: Colts (-4.5)
- Moneyline: Colts (-227), Titans (+187)
- Total: 43.5 points
Colts vs. Titans Prediction
- Pick ATS: Titans (+4.5)
- Pick OU: Over (43.5)
Prediction:
Colts 25 - Titans 21
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Colts vs. Titans Betting Insights
- The Colts have compiled a perfect 2-0-0 record against the spread this season.
- The Titans have a record of 1-1-0 against the spread this year.
- Tennessee has been an underdog by 4.5 points or more two times this year, and covered the spread in one of those matchups.
- Colts games have gone over the point total once this season.
- So far this season, one Titans game has hit the over.
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