ACC opponents match up when the Clemson Tigers (1-2) and the Syracuse Orange (2-1) square off on Saturday, September 20, 2025 at Memorial Stadium (Clemson, SC).
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Clemson vs. Syracuse Matchup Info
- Game date: Saturday, September 20, 2025
- Game time: 12 p.m. ET
- Location: Clemson, South Carolina
- Venue: Memorial Stadium (Clemson, SC)
- TV channel: ESPN
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Clemson vs. Syracuse Odds and Prediction
- Spread favorite: Tigers (-17)
- Moneyline: Tigers (-847), Orange (+574)
- Total: 54.5 points
- Pick ATS: Syracuse (+17)
- Pick OU: Under (54.5)
- Prediction: Clemson 30, Syracuse 18
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Clemson vs. Syracuse Betting Records and Insights
- Clemson has put together a 0-3-0 record against the spread this season.
- Syracuse has covered once in three games with a spread this season.
- The Tigers have not covered the spread this season (0-1 ATS) when playing as at least 17-point favorites.
- Clemson and its opponent have not hit the over yet this season.
- This year, games featuring Syracuse have gone over the point total twice.